Antidotes for Drugs and Toxins (NCLEX)

 

Toxin Antidotes

Toxin	Antidote / Treatment
Acetaminophen (Paracetamol)	N-acetylecysteine
Salicylates	Alkalinize urine, dialysis
Anticholinesterases, organophosphates	Atropine, Pralidoxime
Antimuscarinic, anticholinergic agents	Physostigmine salicylate
Beta blockers	Glucagon
Digitalis	Stop digitalis, normalize K; lidocaine, anti-dig FAB fragments ( Digitoxin) Digitalis Immune FAB
Iron (Ferrous Sulfate)	Deferoxamine
Lead	CaEDTA, dimercaprol, succimer, penicillamine
Arsenic, mercurym gold	Dimercaprol (BAL), succimer
Copper, arsenic, gold	Penicillamine
Cyanide	Nitride, Hydroxocobalamin
Methemoglobin	Methelyn blue
Carbon Monoxide	100% O2, hyperbaric O2
Methanol, ethylene glycol (antifreeze)	Ethanolm dialysism fomepizole
Opioids, Narcotic Analgesics: Demerol and Morphine Sulfate	Naloxone Hydrochloride (Narcan), Naltrexone
Benzodiazepines	Flumazenil (Romazicon)
Tricyclic antidepressants (Anafranil, Tofranil)	NaHCO3 (nonspecific)
Anticoagulant: Heparin	Protamine Sulfate
Anticoagulant: Warfarin	Vitamin K, fresh frozen plasma
Thrombolytics: t-PA, (Streptokinase, Urokinase)	Aminocaproic Acid ( Amicar)
Lithium Carbonate (Eskalith)	Sodium Bicarbonate
Calcium Channel Blocker (Verapamil)	Calcium
Magnesium Sulfate	Calcium Gluconate