Tranexamic Acid or TXA for Bleeding in Trauma
Tranexamic Acid or TXA is an anti-fibrinolytic drug, a synthetic equivalent of the amino acid lysine, and acts opposite to tissue plasminogen activator or rTPA. This is why TXA is sometimes called anti-TPA.
TXA can help to reduce mortality in the acute severely bleeding adult trauma patient if given within three hours of injury.
Contraindications for its use are acquired defective color vision hypersensitivity to TXA or any of its ingredients. Do not give in conjunction with prothrombin complex concentrate such as K Centra, active intravascular clotting and or history of thromboembolism and renal failure.
Indications for use of TXA in the bleeding adult trauma patient are: Administration less than three hours from time of injury, severe hemorrhagic shock with systolic blood pressure below 90 millimeters mercury, heart rate above 110 beats per minute, multi-system trauma with evidence of active hemorrhage, major pelvic fracture with evidence of active hemorrhage, solid organ injuries with evidence of active hemorrhage, and traumatic amputation
How to administer TXA.
A loading dose of one gram TXA is reconstituted in 100 milliliters of normal saline and given intravenously over 30 minutes.
Followed by an intravenous infusion of one gram TXA mixed in 250 ml normal saline over 8 hours.
Watch for adverse side effects such as anaphylaxis, thrombosis, nausea, vomiting, diarrhea, visual disturbances, and hypotension. Stop the infusion and notify the doctor immediately. Follow hospital protocol.
Click the link below for a video about TXA. Thank you.
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